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Both meds can cause an upset stomach such as nausea, vomiting, diarrhea, or constipation

This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue

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Retatrutide and semaglutide are two medications increasingly compared in the context of medical weight management