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A decelerating trajectory is biologically plausible, but without multi-year empirical data we cannot be certain which projection most closely reflects long term real-world outcomes. But she added: Overall, the study reinforces that GLP-1 receptor agonists are unlikely to produce durable weight loss if used as short term interventions without longer term management plans

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Hamedani M, Vatanpour H, Saadat F, Reza Khorramizaheh M, Mirshafiey A