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If constipation goes on for more than seven days, youre at risk for a small bowel obstruction that could require surgery. Still, GLP-1 use has become so popular that some bridal boutiques are asking brides on GLP-1s to sign legal waivers acknowledging that a dress ordered in a certain size may not fit and that the store isnt responsible if continued weight loss creates problems, according to a Wall Street Journal article this spring