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This cascade of reactions affects the expression of glycolysis-related enzymes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase (PFKL), enolase 1 (ENO1), and pyruvate kinase M (PKM), which further promote the transcriptional and metabolic reprogramming of T cells towards their terminal state of exhaustion [25]

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10.1016/j.metabol.2021.154925 18 OelkersP.KirbyL