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Tirzepatide stimulates insulin secretion through the GIPR in human islets from healthy donors, supporting a role for GIPR agonism in its pharmacology (56)

- I would love to see a study done in my community of middle and late middle-aged gay men who are working to balance staying fit (and in many cases bulky or attractively thick as it is often referred to among my people) while also benefiting from AOMs and maintaining a healthy A1C

Yet in most patients this GI distress is not severe enough to stop treatment, though it is reported in approximately 40% of patients (compared to 20% on placebo)

doi: 10.1016/j.pharmthera.2006.11.007 55 MaljaeiMBBahreiniA