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These cells appear to contribute to the aging process and age-related diseases through the senescence-associated secretory phenotype (SASP), which fosters a pro-inflammatory environment detrimental to tissue function and integrity

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4,6 Sulfur metabolism stabilizes one-carbon flux and S-adenosylmethionine (SAM) availability for DNA and histone methylation

First, most studies are limited to correlative studies or short-term in vitro models, and there is little causal evidence linking disrupted organelle interactions to oocyte dysfunction and reduced fertility