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For example, in MC3T3-E1 cells cultured in high glucose, NAC inhibits the PI3K/AKT pathway (Liu and Yang, 2016), while in dexamethasone-stimulated MC3T3-E1 cells and human DFSCs cultured under standard conditions, it activates PI3K signaling (Meng et al., 2022)

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The GHR antagonist pegvisomant is an analog of GH that competes with GH for receptor binding and consequently blocks GHR signal transduction

Older adults and those with malnutrition, chronic disease, or genetic detoxification polymorphisms may benefit more from targeted glutathione support, but individual assessment by a qualified provider is essential before starting supplementation