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We have unimolecular, dual agonist, tri-agonist, [and] tetra-agonists, where you can just add an alkyl group, and then you can tune GLP-1 receptor [sensitivity] up or down, says Kumar

Because the evidence base thins out sharply below the trial population's typical age, leaving less to say about how decades of use would play out

A patient who primarily needs short-term appetite suppression to kickstart a lifestyle change may do better on phentermine

Serious side effects requiring immediate medical attention: Pancreatitis: Severe, persistent abdominal pain that may radiate to the back, often accompanied by nausea and vomiting