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That transient volume contraction, combined with NSAID-mediated renal vasoconstriction, raises the risk of acute kidney injury, particularly in patients who already carry chronic kidney disease, hypertension, or are over 60

Switching from coffee to tea, reducing intake by half, or avoiding caffeine in the afternoon are practical modifications

Analysis suggested an early stress induced changes in the expression of genes with functional redundancy and precise involvement of GSTs in the oxidative stress protection (Sappl et al., 2009)

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