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Fatigue and Cognitive Impairment First-generation antihistamines (like diphenhydramine/Benadryl and hydroxyzine) are notorious for causing drowsiness because they cross the blood-brain barrier and block H1 receptors in the central nervous system

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Although not everyone needs a therapeutic after an injurylimiting the damage after the first concussion may lessen the side effects from the next. More funding needed Korinek says most investors he has talked with understand the commercial potential for concussion therapeutics but need to know that definitive trials can be conducted in heterologous populations, how expensive they will be, and whether big pharma is willing to acquire emergent programs