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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

2.3 Drug administration Albino Wistar female rats were divided randomly into four groups of 10: TIRZ, CIS, CIS + TIRZ, and control