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This review concludes by outlining key drug delivery challenges, including delivery safety and functional integration, that must be addressed to turn this promise into a clinical reality for patients

1, 5 Pharmacological therapies There is some evidence to support the use of acetylcholinesterase-inhibitors, and some other antidementia drugs 1- 3 Non-pharmacological therapies Cognitive training routines have been investigated to improve cognition in PD 1 Some evidence suggests that physical exercise can improve non-motor symptoms, including cognition in patients with PD 1 Again, some studies have suggested deep brain stimulation could be effective in patients with PD and cognitive symptoms 1

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