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The study also found that tirzepatide attenuates alcohol-induced effects on dopamine in the brains reward system, offering insight into its potential mechanisms

Singh KJ, Kaur J

It has been hypothesised that targeting three complementary pathways simultaneously may help to counteract some of the physiological adaptations such as compensatory increases in hunger that can limit the effectiveness of existing treatments, though this remains to be confirmed in clinical studies

Both represent meaningful progress, and the heavier starting weight often sees faster absolute losses even if percentages look lower on paper