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People often notice that benefits feel smoother after several weeksthis reflects the approach to steady state with continued weekly dosing

In subsequent Phase 2 trials, once-weekly subcutaneous injections of retatrutide at doses of 4 mg, 8 mg, and 12 mg resulted in marked improvements in glycemic control compared to placebo, along with substantial weight loss when contrasted with placebo and dulaglutide (1.5 mg)

Previous studies have shown that GLP-1 can inhibit the formation and progression of NAFLD by enhancing lipid metabolism through oxidation and reducing the influx of fatty acids into hepatocytes [104]

However, its important to note that both Semaglutide GLP-1 and Liraglutide can cause gastrointestinal side effects, with a slightly higher incidence in patients taking Semaglutide GLP-1