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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

In addition, mitochondria also play an important role in influencing intracellular calcium levels, reactive oxygen species (ROS) production, regulating innate immune responses, and apoptosis ( Androgens can regulate glucose and lipid metabolism by affecting mitochondrial density, quality, and function

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Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells