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In addition to Ca 2+ , S100A2 also binds to Zn 2+ with higher affinity, and the binding affinity of S100A2 to calcium is significantly reduced upon binding to zinc ( 2+ - and Zn 2+ -ions have opposite effects on the stability of S100A2, with Ca 2+ acting as a protein stabilizer and Zn 2+ as a protein destabilizer ( Figure 2 S100A2 is a member of the S100 EF-hand calcium-binding family found in mammary epithelial cells and other organs or tissues, including the lungs, kidneys, liver, and prostate gland ( Many factors can regulate the distribution and expression levels of S100A2

Specific dosing depends on the condition being treated, administration route, and individual response

Radical is an intermediate species with high chemical activity produced during cellular metabolism, can attack protein, DNA and lipid macromolecule in cell membrane, and damage the physiological function of these macromolecules, making the cell membranes lose their function and shorten the life of cells

2012 Sep 21;3:171