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32 Enzymes play a significant role in maintaining a balance between antioxidants and free radicals by either generating or breaking down ROS

Nat Rev Clin Oncol 18:280296 Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, Wu H, Shi T, Chen W (2021b) Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human caco-2 cells via inhibiting nrf2/ho-1 pathway

Interestingly, a recent study by the Mandrup laboratory has shown that exposure to high glucose (25 mM) elicits a biphasic response in INS-1E cells 43