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Taken together, these findings indicated that hepsin / mice experience heightened oxidative stress in the early stages of APAP exposure, suggesting that endogenous hepsin might protect against toxicity during the early stages of APAP exposure, thereby significantly influencing survival outcomes in drug-induced toxicity cases

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It is carcinogenic (cancer causing), immune suppressive, and can cause liver disease

Gpx4 uses GSH as cofactor and is needed to prevent lipid peroxidation, which depends on ROS