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1 Next Steps and Future Implications These early insights from the COURAGE trial are consistent with recently published pre-clinical data in rodents and non-human primates and clearly establish the principle that blocking GDF8 with or without activin A can preserve muscle and further increase fat loss in patients being treated with GLP-1 therapy, thereby improving the quality of weight loss, continued Yancopoulos, in the press release

Most patients use these medications for several months to over a year, depending on their weight-loss goals and how their bodies respond

Beyond that it cites reports of severe abdominal pain, hospitalization for acute pancreatitis, and permanent gastrointestinal dysfunction following excessive dosing or rapid escalation

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