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Among these, the proactive approach is characterized by the early administration of desmopressin to control renal free water clearance at the beginning of treatment, specifically in patients at increased risk of developing ODS

NPY/Y(1) receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension

Regular monitoring of liver function may be necessary, especially during long-term use

Central Pathways Associated with SGLT-2is Treatment Outcomes To date, only a handful of studies have reported the effects of SGLT-2is on the CNS, mainly due to complexity of SGLTs family, and a lack of research elucidating the exact roles of SGLT-2 in the CNS