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This is particularly important if: Pain is worsening or not responding to prescribed analgesia or hormonal therapy You are experiencing significant side effects from medications You are planning pregnancy and wish to discuss fertility options You have concerns about new or unusual symptoms Patients with deep infiltrating endometriosis or organ involvement should be referred to a specialist endometriosis centre for comprehensive care

Cell 130 , 10951107 (2007)

References [1] Bloise FF, Oliveira TS, Cordeiro A, Ortiga-Carvalho TM

The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy