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REDEFINE 1 included 3,417 participants with overweight or obesity but without diabetes (mean age, 47 years

For patients experiencing significant symptoms, temporarily pausing therapy, maintaining the current dose for an additional 2-4 weeks before advancing, or implementing smaller dose increments when formulation allows, may improve tolerance

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Injectable semaglutide is a weekly subcutaneous injection from a multi-dose vial, $189$289/mo