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In zwf1 cells, we observed sensitive, H 2 O 2 and t -BuOOH concentration-dependent responses for all NAPstar constructs, supporting the conclusion that cytosolic NADP redox homoeostasis is robustly maintained in wild-type yeast by adjusting flux through the oxidative pentose phosphate pathway (Fig

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Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015

How GHK-Cu works Multiple mechanisms : 1