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10.1021/acs.jmedchem.0c02176 20 DelaforestA.DI FurioF.JingR.Ludwig-KubinskiA.TwaroskiK.UrickA.et al (2018)

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Severe liver disease: In patients with advanced liver conditions, such as cirrhosis or liver failure, glutathione therapy should only be administered under medical supervision

4 And it appears that sex hormones may also influence DAO activity, leading to fluctuations in symptoms throughout the menstrual cycle