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Prevalence Heightened intestinal permeability has been demonstrated in the following conditions: Autoimmune Diseases: Celiac disease, type 1 diabetes, autoimmune hepatitis, multiple sclerosis, systemic lupus erythematosus and several other forms of autoimmunity have been linked to intestinal permeability syndrome and excessive bacterial translocation (ref) Psychiatric Disorders: Depression, anxiety, bipolar, schizophrenia (ref) Chronic Kidney Disease and Heart Failure (ref) Inflammatory Bowel Diseases: Conditions like ulcerative colitis and Crohns disease exhibit abnormal gut barrier function with increased intestinal permeability (ref) Functional Gastrointestinal Disorders: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) and small intestinal bacterial overgrowth (ref) Metabolic Disorders: Obesity, metabolic syndrome and diabetes (ref) What causes Leaky Gut Syndrome

[43] Therapeutic [edit] Activation of the NRF2 (nuclear factor erythroid 2related factor 2) pathway has been explored as a therapeutic strategy due to its role in regulating antioxidant and cytoprotective responses

At the same time, diabetes was the second leading cause of obesity-related deaths that year, accounting for approximately 0.6 million deaths and 30.4 million disability-adjusted life-years

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