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Preclinical investigations have showcased the plants capacity to modulate mitochondrial function and apoptosis, as well as mitigate inflammation through the inhibition of inflammatory markers such as cytokines (including IL-6 and TNF-), nitric oxide, and reactive oxygen species

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Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients