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Specific intestinal cells naturally produce GLP-1 after a meal, which activates GLP-1Rs throughout the body to stimulate insulin and suppress glucagon biosynthesis, delay gastric emptying, improve glucose metabolism, and increase satiety

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This question has gained traction as social media influencers tout berberine as "nature's Ozempic," prompting patients and clinicians to examine whether this botanical supplement truly mimics prescription incretin therapies