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PMID: 40020792 JCI Insight S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury

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If youre switching from a progestogen-only-method, you may switch any day from the minipill, from an implant or the IUS on the day of its removal, or from an injectable when the next injection would be due

Nevertheless, the kinetic data for our mutants and rate constants for ScGrx7 and PfGrx between 10 5 10 6 M 1 s 1 are too slow for a diffusion-controlled reaction and point towards important short-lived enzymesubstrate interactions and rate-limiting re-orientations of the substrate at the enzyme surface