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They act as signaling molecules through receptors such as TGR5, influencing glucose metabolism, insulin sensitivity, and energy expenditure

Also, NPY KO mice were less sensitive and NPY overexpressing mice were more sensitive to the sedative effects of alcohol, suggesting that decreased NPY signaling increases tolerance to alcohol intoxication, which could increase drinking (Thiele et al., 1998)

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The plethora of efficacious obesity pharmacotherapies with different mechanisms of action will allow tailored treatment plans based on individuals preference, comorbidities and treatment response