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Weight loss is influenced by genetics, metabolism, insulin sensitivity, hormone levels, lifestyle habits, and medical history

4I, Figure S3C)

This is likely due to structural differences: ipamorelin Aib/D-2-Nal backbone produces a different binding mode at GHS-R1a that may favor specific downstream signaling pathways (biased agonism) compared to the His/D-Trp backbone of GHRP-6