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The traditional view of microglia as simple agents of inflammation has been superseded by an understanding of their complex, dual-purpose functions in brain homeostasis maintenance and immune defense

As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63

By integrating perspectives from biochemistry, metabolism and cancer biology, this review positions CoQ 10 oxidoreductases as promising targets for ferroptosis-based cancer therapies