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Here, we report findings from the PIONEER REAL Netherlands study, which was designed to examine the clinical outcomes associated with the use of once-daily oral semaglutide in routine clinical practice in adults living with T2D, who had not previously been treated with injectable glucose-lowering medication, in the Netherlands (NCT04601740)

J Toxicol Pathol 11, 18389

For gut-wall local effects (ulcer healing, intestinal permeability), the peptide does not need to cross the gut epithelium into systemic circulation