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L-carnitine accomplishes this by binding to acyl residues produced not only from fatty acids but also from amino acid metabolism, forming water-soluble acylcarnitines that facilitate their excretion from cells and ultimately the body (Figure 1) (19, 20)

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One meta-analysis showed that just 1 gram of concentrated berberine significantly lowered cholesterol, BMI, weight, fasting glucose, HbA1C and other metabolic markers