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When You Should Use the Longer (3-Month or More) Timeline Stick with the conservative 3-month approach if youre under 35 and have time to be conservative, youve had extended GLP-1 use (on medication for 6+ months), your baseline cycles were irregular before starting medication (especially with PCOS), youve had significant weight loss (50+ pounds) and need more time for metabolic stabilization, you need time to transition to pregnancy-safe diabetes medications and optimize glucose control, or you have a history of miscarriage and want to optimize conditions

The antidiabetic effect and potential mechanisms of natural polysaccharides based on the regulation of gut microbiota

Dorothy Shulman for her help and contribution to this paper

Collectively, these findings highlight cotadutides dual benefits for glycemic control and liver health, supporting its further development for T2D, obesity, and NASH treatment [85]