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To explore the broader impact of semaglutide on systemic pathophysiology, we performed ultra-sensitive proteomics (NULISA) on plasma samples from both groups of rats (n=12/group)

After expression, total protein levels were measured using an affinity-based detection assay and normalized across samples prior to binding analysis

The Ozempic label includes a warning about acute kidney injury due to volume depletion, noting that reported cases sometimes occurred in patients experiencing nausea, vomiting or diarrhoea leading to dehydration, and directing that renal function be monitored in patients reporting such reactions

Through MALDI-TOF MS, the molecular weight of semaglutide and its related compounds can be determined rapidly and accurately to ensure that the products meet the quality standards