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Immunohistochemically, as noted above, SNUC may show some staining for NSE, but in our experience they have generally lacked staining for most other neuroendocrine markers, including synaptophysin and chromogranin

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They are primarily regulated by the transcription factor forkhead box P3 ( FOXP3 ), which is essential for their development, function and their suppressive activity, any mutations in the FOXP3 gene can impair the Tregs activity, leading to autoimmune disorders

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