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Endogenous importance does not validate every product Water, glucose and insulin are also endogenous or physiologically essential, but their medical effects depend on dose, route, formulation, diagnosis and product quality

Life Sci 80:108793

Adding paragraph (d)(9)

Studies have shown that geniposide exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 and NLRC4 inflammasomes and inhibits the formation of the apoptosis-associated speck-like protein (ASC) complex induced by NLRP3 agonists without affecting the NLRC4 agonist-induced formation of the ASC complex, suggesting that geniposide may affect upstream processes such as autophagy (Yu et al., 2015)