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The GIP receptor is a seven-transmembrane G protein-coupled receptor strongly expressed on islet cells, which has been found in many tissues including the pancreas, adipose tissue, heart, gastrointestinal tract, adrenal cortex, and various neurons in the brain [99]

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The resulting accumulation of inflammatory substances in the perivascular space may activate pial nociceptors, contributing to the onset of migraine and explaining the delayed headache that often follows aura [91]