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Exp Neurol 209:213223 Wang L, Yang HJ, Xia YY, Feng ZW (2010) Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3beta/JNK signaling

Zhang et al., 2012)

Anal Chem 56:18901898 Kelly CP, Cramer CJ, Truhlar DG (2006) Aqueous solvation free energies of ions and ion-water clusters based on an accurate value for the absolute aqueous solvation free energy of the proton

NAC use is based on plotting APAP levels, on the Rumack-Matthew nomogram: Image from Wikipedia [Link is HERE] Intravenous NAC therapy includes: An initial dose of 150 mg/kg over 1 hour, A second dose of 50 mg/kg over 4 hours, And a final infusion of 100 mg/kg over 16 hours