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Indian J Dermatol

Sitravatinib (MGCD516, Mirati Therapeutics, San Diego, California, USA) binds and blocks the activity of several kinases beyond c-MET, including AXL, MERTK, VEGFR1/2/3, DDR2, and members of the tropomyosin-related kinases (TRK), platelet-derived growth factor receptor (PDGFR), and ephrin (Eph) families, among others

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In addition to the work done on Mgll, other research has shown that metformin can promote the phagocytosis of pathological A and tau proteins by enhancing microglial autophagy capability