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The results of a trial of semaglutide in obese patients with HFpEF showed a significant amelioration of symptoms and improvements in motor function and weight loss compared with patients treated with a placebo.470 In this study, researchers randomized 529 patients with heart failure with a preserved ejection fraction and body mass index (weight in kilograms in the square of the height in meters) 30 to receive once-weekly injections of semaglutide (2.4 mg) or placebo for 52 weeks

In cases of obscure bleeding where upper and lower endoscopy are unrevealing, additional modalities including capsule endoscopy, CT enterography, or tagged red blood cell scan may be indicated per ACG small-bowel bleeding guidelines

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