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Such limitations prompted the development of second-generation medicines capable of sustaining stable drug concentrations with reduced dose frequency, hence enhancing both effectiveness and tolerance characteristics

Gastroenterology 132, 21312157, doi: 10.1053/j.gastro.2007.03.054 (2007)

Variants in GLP1R, GIPR, and FTO genes influence how your body's GLP-1 signaling is regulated

It plays a role through a specific GLP-1 receptor (GLP-1R) distributed in many organs or tissues and participates in the regulation of glucose homeostasis in the body

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