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The search strategy combines Medical Subject Headings (MeSH) and keywords including GLP-1, glucagon-like peptide-1 receptor, GLP-1 receptor agonist, sepsis, systemic inflammation, infection, immune response, critical illness, MODS, multiple organ dysfunction, cytokines and sepsis treatment. Articles were screened for relevance based on titles and abstracts, with full-text evaluation of studies addressing the mechanistic or therapeutic implications of GLP-1 signaling in experimental or clinical models of sepsis

Clinical Trials and FDA Approval: Wegovy received FDA approval based on the impressive outcomes of the STEP clinical trials

For example, semaglutide typically starts at a low dose (0.25 mg weekly) and increases to a maintenance dose (2.4 mg weekly for weight loss) over 16 to 20 weeks

These trials should be thoughtfully designed to encompass diverse patient populations, investigate varying doses of GLP-1 RAs, and incorporate extended follow-up periods