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Eliquis IP Valuation The Orange Book listing for apixaban includes the compound patent (estimated expiry 2026 after PTE), two formulation patents with estimated expiry in 2028, and a method-of-use patent for atrial fibrillation

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Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention, which may lead to or exacerbate heart failure, can occur with concomitant use of thiazolidinediones (TZDs) and insulin

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