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Introduction Brain-derived neurotrophic factor (BDNF) Receptors of BDNF and signalling pathways BDNF has neuroprotective effect in experimental stroke models Applications and challenges Conclusion Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation, termed hypoxia-ischemia brain damage (HIBD), which can be caused by extreme prematurity or perinatal asphyxia

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Cell Death Discov 10(1):312 [DOI] [PMC free article] [PubMed] [Google Scholar] Le Gal K, Ibrahim MX, Wiel C et al (2015) Antioxidants can increase melanoma metastasis in mice