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In PD, the essential degeneration process is influenced by several pathophysiological factors, including mitochondrial dysfunction, increased oxidative stress, inflammation, neurotrophic factor deficiency, impairment of the proteasome-autophagia process, and generation of -synuclein oligomers that form the Lewy bodies [2,3,4,5, 43, 44]

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doi: 10.1016/j.jnutbio.2016.12.019 102 JenkinsT

An ideal animal model not only exhibits the same symptoms and pathological changes as a human disease but also follows the same sequence of pathological events