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assuming patients continued oral semaglutide and liraglutide treatment alongside basal insulin before discontinuing and intensifying to basal-bolus insulin therapy when an HbA1c threshold of 8.0% (64 mmol/mol) was exceeded for a second time (with an associated HbA1c reduction applied from the insulin-experienced multivariate equations published by Willis et al.)

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In June 2021, the FDA approved a semaglutide for obese and overweight patients with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol) under the brand name Wegovy

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