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If youve been looking into weight-loss medications, youve no doubt heard of Ozempic, Wegovy, and Mounjaro

Albiglutide is another once-weekly GLP-1 agent that was previously used for diabetes treatment but has been withdrawn from many markets and is no longer commonly prescribed

Steroidal and non-steroidal FXR agonists (e.g., obeticholic acid and newer intestine-biased FXR agonists) consistently improve metabolic dysfunction-associated steatohepatitis histology and reduce liver fibrosis in phase 2 and 3 trials, but their effects on body weight, insulin resistance and systemic inflammatory markers are more modest than anticipated from preclinical studies [269,277,278]

2008;295:E10008