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Animal studies demonstrated dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumours in rodents treated with GLP-1 receptor agonists

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As amylin and GLP-1 target different populations of neurons in the DVC 20 , this suggests that combination drug therapies affecting both systems may provide a greater magnitude and sustainable degree of weight loss compared to monotherapies due to a reduced likelihood of tachyphylaxis 21,22,23

When the next generation of products hits the market, we expect to see scientific innovation in formulation and administration: oral formulations, triple agonists, and once-monthly injections are all not too far from sight