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Here, by adopting a combined biochemical and cell biological approach, we have provided mechanistic information that unveils a surprisingly complex role of PDS5B in HR, DNA damage repair, and replication fork protection

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Dietary modifications that may help reduce symptoms include: Eating smaller, more frequent meals rather than large portions, which can overwhelm the already-delayed gastric emptying Reducing dietary fat intake , as high-fat meals are particularly slow to empty from the stomach Avoiding foods that commonly trigger symptoms such as spicy foods, caffeine, alcohol, and carbonated beverages Eating slowly and chewing thoroughly to reduce the amount of air swallowed and ease the digestive process Staying well hydrated , particularly if experiencing diarrhoea, though avoiding drinking large volumes with meals Identifying and limiting foods high in fermentable carbohydrates (FODMAPs) if bloating and gas are problematicthis approach should ideally be supervised by a dietitian to avoid nutritional compromise Medication management strategies are equally important